Abstract
Background
Inflammatory bowel diseases are associated with various immune- and non-immune-mediated conditions. We aimed to assess the association of inflammatory bowel diseases with comorbidities at late adolescence.
Methods
Jewish Israeli adolescents who underwent a general health evaluation prior to enlistment to the Israeli Defense Forces from 2002 to 2016 were included.
Results
Overall, 891 subjects (595 Crohn’s disease, 296 ulcerative colitis, median age 17.1 years) and 1,141,841 controls were analyzed. Crohn’s disease was associated with arthritis (odds ratio (OR) 4.7, 95% confidence interval (CI) 2.4–9.1), thyroid disease (OR 2.6, 95% CI 1.2–5.5), atopic dermatitis (OR 2, 95% CI 1.1–3.6), autoimmune hepatitis (OR 4.4, 95% CI 2.3–8.6), nephrolithiasis (OR 3.6, 95% CI 1.2–11.4), and pancreatitis (OR 41.8, 95% CI 17.2–101.9). Ulcerative colitis was associated with arthritis (OR 3.6, 95% CI 1.0–9.8), thyroid disease (OR 4.8, 95% CI 1.2–19.4), autoimmune hepatitis (OR 8, 95% CI 4–16.2), and pancreatitis (OR 51, 95% CI 16.1–158.9). Primary sclerosing cholangitis was associated with both diseases. Asthma, celiac, type 1 diabetes, psoriasis, and bone fractures were not more common in both diseases. Male predominance was noted for most associations.
Conclusions
At adolescence, both Crohn’s disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders.
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Acknowledgements
Statistical analysis was performed by Dr. Ron Kedem (PhD), Statistician, Medical Corps, Israel Defense Force, Israel.
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I.G. acquired and analyzed the data and drafted the manuscript. L.H.K., S.D., and R.S. have participated in study design and critically reviewed the manuscript. A.A. was responsible for study conceptualization and design, participated in data analysis, and critically reviewed the manuscript. All authors approve the final version of the manuscript.
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Ghersin, I., Khateeb, N., Katz, L.H. et al. Comorbidities in adolescents with inflammatory bowel disease: findings from a population-based cohort study. Pediatr Res 87, 1256–1262 (2020). https://doi.org/10.1038/s41390-019-0702-3
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DOI: https://doi.org/10.1038/s41390-019-0702-3
