Fig. 2: Gene expression profile in whole blood of children with mild and severe RSV infections.
From: Gene signature of children with severe respiratory syncytial virus infection
a Volcano plot of differentially expressed genes in children with RSV infection. The X-axis represents the log2 differences in gene expression between the two groups with higher positives values indicate increased gene expression (991 genes, red circles) while higher negative values indicate decreased gene expression (676 genes, green circles) in samples from children in the severe RSV group as compared with the mild RSV group. The y-axis represents adjusted p values (−log10 scale) for each gene with higher values indicate greater statistical significance, after adjusting for age, sex, and batch by enrollment year and hospital. The broken horizontal line indicates the 5% false discovery rate. b Heatmap of the 991 upregulated and 676 downregulated genes. Each row represents one gene and column represents one sample. Normalized expression is indicated as upregulated (red) or downregulated (green). Samples are grouped by severe RSV (blue) and mild RSV (yellow).
