Table 3 Multivariable regression models examining the independent effects of the PTGIS SNP haplotype rs493694(G)/rs693649(A) (associated with early ductus closure) on the RNA expression of “ductus closure genes” (n = 273).

From: Interactions between PDA-associated polymorphisms and genetic ancestry alter ductus arteriosus gene expression

Genes/aliases

Regression coefficients for PTGIS

 

Haplotype: rs493694(G)/rs693649(A)

 

General populationa

European ancestryb

Ca2+ signaling

 CACNB2/Cavbeta2

 

−0.469*

K+ channels

  

 KCNS3/Kv9.3

 

−2.454*

Contractile proteins

  

 MYH11/SM1

 

−0.636

Endothelin signaling

  

Prostaglandin signaling

  

 CYP8A1/PTGIS

 

−0.461**

Nitric oxide signaling

  

 NOS3/eNOS

 

−0.618*

Inflammation and remodeling

  

 BMP9

 

−2.22*

 BMP10

−0.513

−1.36*

  1. Regression coefficient represents the increase in a gene’s ΔCT when the PTGIS SNP haplotype was present (compared with when it was absent). Regression coefficients were calculated for each of the 49 “ductus closure genes” listed in Table 1. Regression coefficients are only listed in the table if the association with the “ductus closure gene” has a p value < 0.10. Negative regression coefficients are in italics. *p < 0.05; **p < 0.01.
  2. aGeneral population: multivariate analyses were adjusted for gestational age and genetic ancestry (European or Non-European) without an interaction term between the haplotype and genetic ancestry.
  3. bEuropean ancestry: multivariate analyses were adjusted for gestational age and genetic ancestry (European or Non-European) plus an interaction term between the haplotype and genetic ancestry; regression coefficients were obtained for the referent value: European genetic ancestry.
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