Abstract
Background
Bronchopulmonary dysplasia (BPD) is the most common morbidity complicating preterm birth and affects long-term respiratory outcomes. The objectives of this study were to establish whether serum periostin at birth, day of life (DOL) 28, and corrected 36 weeks’ gestational age could be potential biomarkers for BPD.
Methods
A total of 98 preterm Japanese infants born at <32 weeks and comparing 41 healthy controls born at term, were divided into BPD (n = 44) and non-BPD (n = 54) cohorts. Serum periostin levels were measured using an enzyme-linked immunosorbent assay.
Results
Among 98 preterm infants, the median serum periostin levels at birth were higher with BPD (338.0 ng/mL) than without (275.0 ng/mL, P < 0.001). Multivariate analysis revealed that serum periostin levels at birth were significantly associated with BPD (P = 0.013). Serum periostin levels at birth with moderate/severe BPD (345.0 ng/mL) were significantly higher than those with non-BPD/mild BPD (283.0 ng/mL, P = 0.006).
Conclusions
Serum periostin levels were significantly correlated with birth weight and gestational age, and serum periostin levels at birth in BPD infants were significantly higher than that in non-BPD infants.
Impact
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This study found higher serum periostin levels at birth in preterm infants subsequently diagnosed with bronchopulmonary dysplasia.
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It also emerged that serum periostin levels at birth significantly correlated with gestational age and birth weight.
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The mechanism by which serum periostin is upregulated in BPD infants needs further investigation.
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Acknowledgements
Junya Ono is a salaried employee of Shino-Test Co., Ltd., which provided ELISA for periostin without stipulations or influence over the interpretation of test results. The authors have no other potential or actual conflicts of interest pertaining to the contents of this article.
Funding
This work was supported by Grants-in-Aid Scientific Research from the Japan Society for the Promotion of Science, KAKENHI (Grant number: 20K08233).
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H.G. designed the study, carried out the analyses, and drafted multiple iterations of the manuscript. H.O., K.N., S.N., K.I., and M.H. supervised the study and edited the manuscript. J.O. carried out the analyses and reviewed the manuscript. H.M., K.O., M.S., K.S., M.C., Y.K., H.I., Y.K., N.K., and K.H. collected the samples and reviewed the manuscript. All authors concur with the final manuscript are accountable for all aspects of the work.
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Junya Ono is a salaried employee of Shino-Test Co., Ltd. The remaining authors declare no competing interests.
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Go, H., Ono, J., Ohto, H. et al. Can serum periostin predict bronchopulmonary dysplasia in premature infants?. Pediatr Res 92, 1108–1114 (2022). https://doi.org/10.1038/s41390-021-01912-w
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DOI: https://doi.org/10.1038/s41390-021-01912-w
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