Table 2 Clinical features and MRI patterns of brain injury in infants with mild HIE who received therapeutic hypothermia, compared to those who did not receive therapeutic hypothermia.
From: Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury
All N = 142 | Therapeutic hypothermia N = 121 | No therapeutic hypothermia N = 21 | P value | |
|---|---|---|---|---|
Clinical features | ||||
Gestational age (mean, weeks) | 39.2 | 39.3 | 38.8 | 0.92 |
Birthweight (mean, grams) | 3292 | 3389 | 3276 | 0.41 |
Male | 91 (64%) | 17 (81%) | 74 (61%) | 0.08 |
Lowest cord pH (mean) | 7.0 | 7.0 | 7.0 | 0.57 |
5-minute Apgar (median, range) | 5 (3–6) | 4 (3–6) | 7 (5–8) | <0.0001 |
10-minute Apgar (median, range) | 6 (5–7) | 6 (5–7) | 6 (5–8) | 0.54 |
Brain MRI | ||||
Age at scan (median, days) | 5 (4–6) | 5 (4–7) | 4 (3–4) | <0.001 |
Brain injury present | 87 (61%) | 72 (60%) | 15 (71%) | 0.30 |
Pattern of injury | ||||
Normal | 55 (39%) | 49 (40%) | 6 (29%) | 0.30 |
Watershed | 32 (23%) | 22 (18%) | 10 (48%) | 0.002 |
Deep gray | 28 (20%) | 24 (20%) | 4 (19%) | 0.92 |
Punctate white matter | 24 (17%) | 19 (16%) | 5 (24%) | 0.48 |
Focal parenchymal | 12 (8%) | 10 (8%) | 2 (10%) | 0.95 |
Arterial ischemic stroke | 5 (4%) | 4 (3%) | 1 (5%) | 0.62 |
Hippocampal | 2 (1%) | 2 (2%) | 0 (0%) | 0.53 |
Atypicala | 27 (19%) | 25 (21%) | 2 (10%) | 0.29 |
Multiple patterns | 31 (22%) | 26 (21%) | 5 (24)% | 0.26 |
