Abstract
Objective
To describe renal regional saturation of oxygen (RrSO2) values during the first week of life for preterm neonates born at <32 weeks gestational age (GA).
Methods
RrSO2 values recorded over the first week of life using near-infrared spectroscopy were retrospectively analyzed in this two-center cohort study of preterm infants without known congenital anomalies of the kidney.
Results
A cohort of 109 neonates with a median GA of 26.9 weeks and a median of 120 (IQR: 87–141) hours of continuous RrSO2 monitoring were included. Separately fitted trends in RrSO2 did not differ (p = 0.52) between sites and demonstrated a consistent decrease in RrSO2 by 20 points (95% CI: 9.6–30.1) during the first 60 h of life, followed by a stabilization of RrSO2 thereafter. RrSO2 baseline trends increased by 2.1 (95% CI: 0.8–3.3) percentage points for each additional week GA between 24 and 32 weeks GA.
Conclusions
Despite differences in adjusted RrSO2 values between sites, profiles over time are consistent, allowing for the determination of RrSO2 trajectories in preterm infants. This expected pattern of RrSO2 changes in the first week may help guide future investigations and interventions to identify and reduce kidney injury in the preterm neonate.
Impact
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Renal regional saturation of oxygen (RrSO2) slowly decreases during the first 60 h of age in <32-week preterm neonates.
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While site differences were identified with respect to absolute values, RrSO2 trends from two different centers were not different.
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Lower gestational age neonates have lower RrSO2 levels during the first week.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
We would like to thank the Meriter Foundation for funding the initial trial at UPHM. We would like to thank the families for agreeing to participate in the study.
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M.W.H.: significant contributions to the design and conception, data analysis and interpretation, drafting the manuscript, critical revision of the manuscript and final approval. P.E.C.: analysis and interpretation of data; drafting the article and revising it critically for important intellectual content; and final approval of the version to be published. J.E.C.: collection and interpretation of data; and final approval of the version to be published. M.R.L.: analysis of data and drafting methods/parts of results and review/approval of manuscript. V.Y.C.: significant contributions to the design and conception, data analysis and interpretation, drafting the manuscript, critical revision of the manuscript and final approval.
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The authors have no financial disclosures. V.Y.C. is supported by the Stanford Maternal and Child Health Research Institute. M.W.H. is supported by the Wisconsin Partnership Program New Investigator Award and an institutional KL2 award (KL2TR002374).
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Harer, M.W., Condit, P.E., Chuck, J.E. et al. Renal oxygenation measured by near-infrared spectroscopy in preterm neonates in the first week. Pediatr Res 92, 1744–1748 (2022). https://doi.org/10.1038/s41390-022-02036-5
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DOI: https://doi.org/10.1038/s41390-022-02036-5
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