Abstract
Background
We analyzed the demographic and clinical characteristics of children with immunoglobulin A (IgA) nephropathy using data in the first pages of electronic health records of 22 hospitals from 2016 to 2018.
Methods
Information collected included gender, age, infection site, etiological infection, acute kidney injury (AKI), and chronic kidney disease (CKD) stages 2–5. We analyzed the gender and age distribution of children with IgA nephropathy, the characteristics of children complicated with AKI and CKD, and the influence of geographical distribution and economic status on the incidence of IgA nephropathy.
Results
We included a total of 4006 patients with IgA nephropathy. Incidence in males gradually increased with age. Seventy-nine cases (1.97%) had AKI. We found no significant difference in gender (P = 0.19) or age (P = 0.07) between the AKI and non-AKI groups. Twenty-nine patients had CKD (0.72%), who were significantly older than those in the non-CKD group (P < 0.0001). The incidence of IgA nephropathy in less-developed areas was significantly lower than that in developed areas (P = 0.0002).
Conclusions
The incidence of IgA nephropathy was high mainly in males. Age was an important factor affecting CKD. The disease was related to environment and economic status.
Impact
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We analyze the demographic and clinical characteristics of children with immunoglobulin A (IgA) nephropathy using data in the first pages of electronic health records.
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This is a large sample, multi-center study.
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The incidence of IgA nephropathy in males increased gradually with age.
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Age was an important factor affecting CKD.
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The disease was related to environment and economic status.
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The materials described in the manuscript, including all relevant raw data, will be freely available to any researcher wishing to use them for non-commercial purposes, without breaching participant confidentiality.
References
The Subspecialty Group of Nephrology. The Society Pediatrics, Chinese Medical Association. Clinical and pathological manifestations of Chinese childhood patients with primary IgA nephropathy: a national collaborative study of 33 hospitals. Chin. J. Pediatr. 45, 272–278 (2007).
Working Group for National Survey on Status of Diagnosis and Treatment. Multicenter investigation of therapeutic status of children with IgA nephropathy in China. Chin. J. Pediatr. 51, 486–490 (2013).
Wang, L. et al. The disease spectrum analysis of children’s nephrology department in a hospital from 2014 to 2019. Chin. Med. Rec. 21, 65–68 (2020).
Zhou, Q. et al. Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study. Ren. Fail. 40, 657–664 (2018).
Pérez, A. et al. IgA-dominant infection-associated glomerulonephritis following SARS-CoV-2 infection. Viruses 13, 587 (2021).
Shirai, Y. et al. Rapid progression to end-stage renal disease in a child with IgA-dominant infection-related glomerulonephritis associated with parvovirus B19. CEN Case Rep. 9, 423–430 (2020).
Filippatos, F., Tatsi, E. B. & Michos, A. Immune response to SARS-CoV-2 in children: a review of the current knowledge. Pediatr. Investig. 5, e12283 (2021). Online ahead of print.
Feriozzi, S. & Polci, R. The role of tonsillectomy in IgA nephropathy. J. Nephrol. 29, 13–19 (2016).
Osamu, H. & Takashi, O. The epipharynx-kidney axis triggers glomerular vasculitis in immunoglobulin A nephropathy. Immunol. Res. 67, 304–309 (2019).
Cox, S. N. et al. Activated innate immunity and the involvement of CX3CR1-fractalkine in promoting hematuria in patients with IgA nephropathy. Kidney Int. 82, 548–560 (2012).
Hotta, O., Tanaka, A. & Oda, T. Chronic epipharyngitis: a missing background of IgA nephropathy. Autoimmun. Rev. 18, 835–836 (2019).
Chen, C. J., Wu, G. H., Kuo, R. L. & Shih, S. R. Role of the intestinal microbiota in the immunomodulation of influenza virus infection. Microbes Infect. 19, 570–579 (2017).
Riispere, Ž. et al. IgA nephropathy clinicopathologic study following the Oxford classification: progression peculiarities and gender-related differences. Medicina 52, 340–348 (2016).
Kiryluk, K. et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet. 8, e1002765 (2012).
Schena, F. P. & Nistor, I. Epidemiology of IgA nephropathy: a global perspective. Semin. Nephrol. 38, 435–442 (2018).
Acknowledgements
We thank the members of Futang Research Center of Pediatric Development for the information of electronic health records, including Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China; Dalian Children’s Hospital of Dalian Medical University, Dalian, China; Children’s Hospital of Hebei Province, Shijiazhuang, China; Inner Mongolia Autonomous Region Maternal and Child Health Hospital, Hohhot, China; Shanxi Children’s Hospital, Shanxi Maternal and Child Health Care Hospital, Taiyuan, China; Anhui Children’s Hospital, Hefei, China; Hangzhou Children’s Hospital, Hangzhou, China; Jinan Children’s Hospital, Jinan, China; The Affiliated Children’s Hospital of Nanchang University, Jiangxi Provincial Children’s Hospital, Nanchang, China; Liaocheng Children’s Hospital, Liaocheng, China; Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China; Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China; Shenzhen Children’s Hospital, Shenzhen, China; Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hunan Children’s Hospital, Changsha, China; Henan Children’s Hospital, Zhengzhou Children’s Hospital, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, China; Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu Province, China; Women and Children’s Hospital of Qinghai Province, Xining, Qinghai, China; Urumqi Children’s Hospital, Urumqi, China; The Children’s Hospital of Xi’an City, Xi’an, China; Guiyang Children’s Hospital, Guiyang, China; and Kunming Children’s Hospital, Kunming, China. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.
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N.Z., H.W., X.-y.W., and G.-s.F.: conception and design; N.Z., X.-y.W., Y.-p.J., Q.F., and Y.L.: acquisition of data or analysis; N.Z.: interpretation of the data and for drafting the article; H.W. revising the article critically; N.Z.: final approval of the version to be published.
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Zhou, N., Wang, H., Wang, Xy. et al. Characteristics of children with IgA nephropathy. Pediatr Res 93, 715–719 (2023). https://doi.org/10.1038/s41390-022-02080-1
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DOI: https://doi.org/10.1038/s41390-022-02080-1
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