Table 2 Metabolite ratios.

From: Neurometabolic changes in neonates with congenital heart defects and their relation to neurodevelopmental outcome

 

Healthy controls

CHD pre-surgery

CHD post-surgery

Missing data

n

30

62

67

 

Gestational age at scan

42.5 (1.9)

40.2 (1.4)

43.0 (2.0)

0

Basal ganglia

  NAA/Cho

2.2 (0.31)

1.76 (0.21)

2.13 (0.44)

2

  Cho/Cr

0.36 (0.04)

0.39 (0.04)

0.37 (0.07)

2

  NAA/Cr

0.78 (0.1)

0.69 (0.07)

0.79 (0.12)

2

  mI/Cr

0.75 (0.19)

0.82 (0.15)

0.77 (0.24)

2

  Glu/Cr

1.02 (0.19)

0.97 (0.19)

1.08 (0.25)

2

  Glx/Cr

1.53 (0.37)

1.56 (0.38)

1.71 (0.49)

2

  Lac/Cr

0.09 [0.00, 0.15]

0.11 [0.04, 0.17]

0.11 [0.04, 0.15]

2

White matter

  NAA/Cho

2.14 (0.35)

1.57 (0.26)

2.00 (0.45)

17

  Cho/Cr

0.49 (0.07)

0.54 (0.07)

0.48 (0.08)

17

  NAA/Cr

1.04 (0.15)

0.83 (0.11)

0.96 (0.16)

17

  mI/Cr

1.4 (0.27)

1.55 (0.29)

1.35 (0.31)

17

  Glu/Cr

1.35 (0.29)

1.31 (0.32)

1.40 (0.32)

17

  Glx/Cr

2.15 (0.55)

2.18 (0.52)

2.12 (0.53)

17

  Lac/Cr

0.17 [0.08, 0.29]

0.24 [0.14, 0.33]

0.19 [0.07, 0.32]

17

  1. Stratified by group and timepoint of measurement. Reported as mean and standard deviation (m (SD)). Lac/Cr is reported as median and interquartile range (m [IQR]) as it was nonnormally distributed. Missing data show the percentage of data missing in the dataset that was imputed.
  2. NAA N-acetylaspartate, Cho choline, Cr creatine, mI myo-Inositol, Glx glutamate and glutamine, Glu glutamate, Lac lactate.
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