Table 3 Cytokine concentrations (pg/mL) expressed as means (SDs) in patients with FSs during first FSs, during febrile episodes without FSs, during recurrent FSs, and during a healthy period after FS and in controls.
From: Recurrent febrile seizures and serum cytokines: a controlled follow-up study
FS patients | Controls | P-values | |||||||
|---|---|---|---|---|---|---|---|---|---|
Cytokine | First FS N = 17 | Fever w/o FS N = 17 | Recurrent FS N = 17 | Healthy after FS N = 17 | Febrile children N = 17 | Healthy adults N = 17 | First FS vs. Febrile children | Recurrent FS vs. Febrile children | Healthy after FS vs. Healthy adults |
Anti-inflammatory | |||||||||
IL-1RA (SD) | 2580 (1516) | 1336 (1364) | 2666 (1747) | 474 (901) | 746 (551) | 382 (968) | <0.001* | 0.001* | NS |
IL-4 (SD) | 90(169) | 217 (418) | 272 (791) | 693 (2258) | 78 (136) | 64 (76) | NS | NS | NS |
IL-10 (SD) | 66 (86) | 137 (311) | 366 (1231) | 1317 (5184) | 76 (140) | 47 (87) | NS | NS | NS |
Pro-inflammatory | |||||||||
IL-1β (SD) | 37 (66) | 184 (398) | 203 (584) | 442 (1447) | 65 (125) | 149 (417) | NS | NS | NS |
IL-2 (SD) | 151 (286) | 345 (621) | 529 (1468) | 1102 (3554) | 495 (1106) | 182 (312) | NS | NS | NS |
IL-5 (SD) | 189 (372) | 504 (1135) | 4042 (15,721) | 9835 (39,587) | 1139 (3894) | 358 (905) | NS | NS | NS |
IL-6 (SD) | 114 (98) | 350 (1010) | 933 (3308) | 1630 (6181) | 110 (116) | 42 (67) | NS | NS | 0.034* |
IL-8 (SD) | 1245 (2852) | 362 (900) | 926 (1602) | 833 (1429) | 325 (372) | 267 (578) | NS | NS | NS |
IL-12p70 (SD) | 16 (6) | 61 (143) | 36 (72) | 157 (546) | 20 (26) | 16 (9) | NS | NS | NS |
TNF-α (SD) | 26 (37) | 194 (519) | 137 (414) | 903 (3427) | 51 (111) | 21 (22) | NS | NS | NS |
TNF-β (SD) | 54 (127) | 183 (377) | 287 (788) | 608 (2034) | 56 (100) | 69 (138) | NS | NS | NS |
IFN-γ (SD) | 306 (726) | 1210 (2718) | 3528 (13,293) | 14058 (55,267) | 218 (383) | 104 (206) | NS | NS | NS |
Ratios | |||||||||
IL-1RA/IL-1β (SD) | 250 (325) | 78 (102) | 665 (2168) | 10 (14) | 58 (96) | 60 (219) | 0.002* | NS | NS |
IL-1RA/IL-6 (SD) | 35 (23) | 23 (29) | 46 (51) | 14 (21) | 12 (13) | 14 (14) | 0.006* | 0.017* | NS |
IL-1RA/IL-8 (SD) | 60 (88) | 100 (217) | 29 (59) | 4 (7) | 20 (35) | 21 (37) | NS | NS | NS |
