Table 3 Metabolites responsive to both initiation and cessation of tapering dose HC treatment.

From: The hydrocortisone-responsive urinary metabolome of premature infants

  

Off/on HC treatment analysis

Post/pre HC

Chemical name

Super pathway

HC stopped (n = 7)

HC continued (n = 7)

(n = 14)

  

Mean

SD

p

Mean

SD

p

Mean

SD

p

Leucylglycine

Peptide

4.83

4.80

0.007

1.62

1.31

0.7454

0.65

0.79

0.031

Isoleucine

Amino acid

2.28

1.60

0.017

1.23

1.02

0.8410

0.87

0.40

0.034

2-Hydroxyhippurate

Xenobiotics

4.24

4.03

0.020

1.20

0.55

0.7557

0.63

0.69

0.022

Isocitrate

Energy

6.12

3.89

0.024

4.27

5.28

0.2658

0.65

0.60

0.035

Isovalerylglutamine

Amino acid

0.51

0.33

0.024

1.67

3.26

0.0481

4.52

5.95

0.008

3-Methylcrotonylglycine

Amino acid

0.62

0.37

0.024

1.03

0.21

0.7320

4.10

4.71

0.008

X-24332

 

4.72

4.28

0.028

3.82

7.02

0.4830

0.68

0.47

0.013

X-12101

 

2.95

1.48

0.029

1.30

0.98

0.4555

0.75

0.37

0.008

Phenylalanylglycine

Peptide

2.12

1.00

0.033

1.50

0.86

0.2826

0.75

0.51

0.033

X-10458

 

2.59

1.47

0.033

1.17

0.84

0.9101

0.73

0.30

0.004

X-18887

 

1.89

0.86

0.034

1.35

0.77

0.4101

0.69

0.46

0.013

X-24341

 

4.03

2.37

0.034

3.21

5.76

0.5111

0.68

0.67

0.011

Pro-hydroxy-pro

Amino acid

1.98

0.95

0.035

1.65

1.01

0.1605

0.75

0.44

0.031

Leucylhydroxyproline

Peptide

3.60

2.10

0.036

2.40

1.98

0.2508

0.73

0.53

0.036

X-17842

 

2.21

1.39

0.041

1.08

0.72

0.8538

0.75

0.34

0.011

3-Methylcytidine

Nucleotide

1.42

0.46

0.041

1.35

0.64

0.2253

0.81

0.24

0.018

Homocitrate

Energy

2.74

1.73

0.041

1.66

1.28

0.2430

0.79

0.40

0.012

X-23665

 

4.56

5.17

0.044

1.29

0.96

0.6991

0.79

0.86

0.028

Mevalonolactone

Lipid

2.88

1.91

0.045

1.70

1.57

0.4946

0.76

0.29

0.003

Glycerate

Carbohydrate

2.84

2.46

0.045

1.96

2.15

0.3226

0.86

0.24

0.043

Erythronate

Carbohydrate

1.53

0.54

0.047

1.22

0.45

0.2425

0.75

0.22

0.007

N-methylproline

Amino acid

6.74

6.71

0.048

5.78

12.17

0.4349

0.71

0.46

0.012

X-23678

 

3.41

2.18

0.048

2.74

3.54

0.3114

0.76

0.54

0.006

  1. Data are for 23 chemicals with p < 0.05 in both off/on analysis after stopping HC and in post/pre on starting HC. Five chemicals with a change in the same direction for off/on (stop HC) and post/pre (start HC) are not shown. p values by paired t-test of normalized chemical abundance. Only 10.5% of metabolites regulated at p < 0.05 on starting HC remain responsive at the lowest dose of HC before stopping treatment.
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