Table 2 Experts’ report of therapies applied during LISA.

From: Curriculum and assessment tool for less invasive surfactant administration: an international Delphi consensus study

Category

Results

Report of gestational age for eligible infants, median [IQR], range

28 [24–32], 22–42

Report of analgesic/sedative pharmacological treatment, n (%)a

  Fentanyl

75 (49%)

  Propofol

28 (18%)

  Ketamine

17 (11%)

  Lidocain spray

2 (1%)

  Midazolam

7 (5%)

  Phenobarbital

2 (1%)

  Morphine

7 (5%)

  Sufentanil

1 (1%)

  No use of analgesics/sedatives

63 (41%)

Report of non-pharmacological treatment, n (%)a

  Swaddling/wrapping

89 (58%)

  Sucrose

73 (48%)

  Tucking

70 (46%)

  Skin-to-skin care

23 (15%)

  Environment (light and noise reduction)

19 (12%)

  Containment/holding

15 (10%)

  Positioning

10 (7%)

  Non-nutritive suctioning

6 (4%)

  NIDCAP principles

3 (2%)

  Human milk

3 (2%)

  No use of non-pharmacological treatment

6 (4%)

Report of surfactant used, n (%)

  Curosurf/Poractant alfa/Porcine surfactant

125 (94%)

  Calsurf/Bovine surfactant

8 (6%)

Report of pre-procedure pharmacological treatment, n (%)a

  Caffeine

138 (90%)

  Atropine

35 (23%)

  Paracetamol

2 (1%)

  No use of pre-procedure pharmacological treatment

11 (7%)

Report of post-procedure pharmacological treatment, n (%)a

  Naloxone

36 (24%)

  Caffeine

7 (5%)

  Theophylline

1 (1%)

  Paracetamol

1 (1%)

  Antibiotics

1 (1%)

  Atropine

1 (1%)

  Doxapram

1 (1%)

  No use of post-procedure pharmacological treatment

106 (69%)

Report of respiratory support during LISA, n (%)a

  nCPAP

129 (84%)

  NIPPV

71 (46%)

  HFNC

14 (9%)

  Other respiratory support during LISA

9 (6%)

  1. Therapies applied during LISA according to the 153 experts.
  2. HFNC high-flow nasal cannula, IQR interquartile range, LISA less invasive surfactant administration, nCPAP nasal continuous positive airway pressure, NIDCAP Newborn Individualized Developmental Care and Assessment Program, NIPPV nasal intermittent positive pressure ventilation.
  3. aMore than one option could be chosen.