Fig. 2: Suppression of renal tubulointerstitial fibrosis in FAN mice by Tie2 mAb treatment.
From: Reduction of renal interstitial fibrosis by targeting Tie2 in vascular endothelial cells
a Masson staining was performed to evaluate tubulointerstitial fibrosis in murine renal tissues (magnification, ×200). b Semiquantitative score of tubulointerstitial fibrosis in Masson’s trichrome-stained sections. Ten randomly selected high-power fields were quantified and the average value was calculated for each mouse. c Expression of FSP1 in murine renal tissues was assessed by immunohistochemical staining (magnification, ×400). d The number of infiltrating FSP1-positive cells in kidneys was counted. All data are expressed as mean ± SD (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001. FSP1 fibroblast-specific protein 1.
