Table 4 Multivariable linear regression analyses of the relation (β estimate and 95% confidence interval) of prenatal acetaminophen exposure with language outcomes on the MB-CDI at 2 years.

From: Examining the relationship of acetaminophen use during pregnancy with early language development in children

Outcome

  

Stratified by Sex

 

Unadjusteda

Exposure

Main Effect

Females

Males

Vocabulary

1st Trimester

−0.44 (−1.31, 0.43)

−0.66 (−2.18, 0.85)

−0.33 (−1.39, 0.73)

2nd Trimester

*−0.69 (−1.24, −0.14)

−0.83 (−1.57, −0.09)

−0.51 (−1.34, 0.31)

3rd Trimester

**−1.95 (−3.26, −0.65)

−1.89 (−3.59, −0.19)

−2.05 (−4.09, 0.003)

Entire Pregnancy

*−0.41 (−0.74, −0.09)

−0.50 (−0.94, −0.05)

−0.33 (−0.79, 0.13)

Mean Length of Utterance

1st Trimester

−0.005 (−0.02, 0.01)

−0.004 (−0.03, 0.02)

−0.01 (−0.02, 0.01)

2nd Trimester

†−0.007 (−0.01, 0.001)

−0.01 (−0.02, 0.002)

−0.005 (−0.02, 0.01)

3rd Trimester

*−0.02 (−0.04, −0.0004)

−0.02 (−0.05, 0.001)

−0.02 (−0.05, 0.02)

Entire Pregnancy

†−0.004 (−0.01, 0.001)

−0.005 (−0.01, 0.001)

−0.003 (−0.01, 0.004)

Complexity

1st Trimester

−0.04 (−0.11, 0.02)

−0.05 (−0.16, 0.07)

−0.04 (−0.12, 0.03)

2nd Trimester

−0.02 (−0.07, 0.02)

−0.03 (−0.11, 0.06)

−0.02 (−0.08, 0.04)

3rd Trimester

−0.04 (−0.15, 0.07)

−0.01 (−0.16, 0.14)

−0.08 (−0.26, 0.09)

Entire Pregnancy

−0.02 (−0.04, 0.01)

−0.02 (−0.06, 0.03)

−0.02 (−0.05, 0.01)

Adjustedb

Vocabulary

1st Trimester

−0.28 (−1.14, 0.58)

−0.48 (−1.97, 1.02)

−0.18 (−1.23, 0.87)

2nd Trimester

*−0.58 (−1.13, −0.04)

−0.78 (−1.52, −0.05)

−0.33 (−1.16, 0.50)

3rd Trimester

**−1.83 (−3.13, −0.54)

−1.78 (−3.46, −0.11)

−1.91 (−3.93, 0.11)

Entire Pregnancy

*−0.35 (−0.67, −0.03)

−0.45 (−0.90, −0.01)

−0.24 (−0.70, 0.22)

Mean Length of Utterance

1st Trimester

−0.002 (−0.01, 0.01)

−0.002 (−0.02, 0.02)

−0.003 (−0.02, 0.01)

2nd Trimester

†−0.01 (−0.01, 0.001)

−0.01 (−0.02, 0.001)

−0.003 (−0.02, 0.01)

3rd Trimester

*−0.02 (−0.04, −0.003)

−0.02 (−0.05, −0.001)

−0.02 (−0.06, 0.01)

Entire Pregnancy

−0.004 (−0.01, 0.001)

−0.01 (−0.01, 0.001)

−0.002 (−0.01, 0.005)

Complexity

1st Trimester

−0.03 (−0.10, 0.03)

−0.04 (−0.15, 0.07)

−0.03 (−0.10, 0.05)

2nd Trimester

−0.02 (−0.07, 0.03)

−0.02 (−0.10, 0.06)

−0.01 (−0.07, 0.05)

3rd Trimester

−0.04 (−0.15, 0.08)

−0.0003 (−0.15, 0.15)

−0.08 (−0.26, 0.09)

Entire Pregnancy

−0.01 (−0.04, 0.01)

−0.01 (−0.06, 0.03)

−0.01 (−0.05, 0.02)

  1. aUnadjusted models were adjusted for child sex and age.
  2. bAll models were adjusted for child sex and age at assessment, maternal parity, maternal education, mean perceived stress during pregnancy, and mean depression during pregnancy.
  3. †p < 0.10; *p < 0.05; **p < 0.01.
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