Table 5 Odds ratios (odds, 95% CI) of children with prenatal acetaminophen exposure having a percentile score ≤25th percentile adjusted for child sex and age.

From: Examining the relationship of acetaminophen use during pregnancy with early language development in children

Outcome

  

Stratified by Sex

 

Unadjusted

Exposure

Main Effect

Females

Males

Vocabulary

1st Trimester

1.003 (0.99, 1.01)

†1.02 (0.99, 1.04)

0.99 (0.98, 1.01)

2nd Trimester

1.01 (0.99, 1.01)

1.01 (0.99, 1.02)

1.004 (0.99, 1.01)

3rd Trimester

†1.02 (0.99, 1.03)

1.02 (0.99, 1.04)

1.01 (0.99, 1.04)

Entire Pregnancy

1.003 (0.99, 1.01)

†1.01 (0.99, 1.01)

1.001 (0.99, 1.01)

Mean Length of Utterance

1st Trimester

0.996 (0.98, 1.01)

0.99 (0.97, 1.02)

0.99 (0.96, 1.02)

2nd Trimester

1.004 (0.99, 1.01)

1.01 (0.99, 1.02)

0.99 (0.98, 1.02)

3rd Trimester

†1.02 (0.99, 1.04)

1.01 (0.99, 1.03)

†1.03 (0.99, 1.07)

Entire Pregnancy

1.002 (0.99, 1.01)

1.003 (0.99, 1.01)

1.001 (0.99, 1.01)

Complexity

1st Trimester

1.003 (0.99, 1.02)

1.01 (0.99, 1.03)

0.93 (0.77, 1.12)

2nd Trimester

1.001 (0.99, 1.01)

1.01 (0.99, 1.02)

0.99 (0.92, 1.06)

3rd Trimester

1.02 (0.99, 1.04)

1.003 (0.97, 1.03)

*1.04 (1.01, 1.09)

Entire Pregnancy

1.002 (0.99, 1.01)

1.004 (0.99, 1.01)

1.00 (0.99, 1.01)

Adjusteda

Vocabulary

1st Trimester

1.002 (0.99, 1.01)

1.02 (0.99, 1.04)

0.99 (0.98, 1.01)

2nd Trimester

1.01 (0.99, 1.01)

1.01 (0.99, 1.02)

1.003 (0.99, 1.01)

3rd Trimester

†1.02 (0.99, 1.03)

1.02 (0.99, 1.04)

1.01 (0.99, 1.04)

Entire Pregnancy

1.003 (0.99, 1.01)

1.01 (0.99, 1.01)

1.001 (0.99, 1.01)

Mean Length of Utterance

1st Trimester

0.99 (0.98, 1.01)

0.99 (0.97, 1.02)

0.99 (0.96, 1.03)

2nd Trimester

1.003 (0.99, 1.01)

1.004 (0.99, 1.01)

0.99 (0.98, 1.02)

3rd Trimester

†1.02 (0.997, 1.04)

1.01 (0.98, 1.03)

*1.05 (1.01, 1.09)

Entire Pregnancy

1.002 (0.99, 1.01)

1.002 (0.99, 1.01)

1.003 (0.99, 1.01)

Complexity

1st Trimester

1.01 (0.99, 1.02)

1.01 (0.99, 1.03)

0.95 (0.78, 1.15)

2nd Trimester

1.003 (0.99, 1.02)

1.003 (0.99, 1.02)

0.99 (0.93, 1.05)

3rd Trimester

1.02 (0.99, 1.04)

1.003 (0.97, 1.04)

*1.07 (1.01, 1.13)

Entire Pregnancy

1.003 (0.99, 1.01)

1.003 (0.99, 1.01)

1.004 (0.99, 1.02)

  1. aAll models were adjusted for maternal parity, maternal education, mean perceived stress during pregnancy, and mean depression during pregnancy.
  2. †p < 0.10; *p < 0.05; **p < 0.01.
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