Table 6 Multivariable linear regression analyses of the relation (β estimate and 95% confidence interval) of prenatal acetaminophen exposure with language outcomes on the SLAS at 3 years.

From: Examining the relationship of acetaminophen use during pregnancy with early language development in children

Unadjusteda

Stratified by Sex

Exposure

Main Effect

Females

Males

1st Trimester

†−0.07 (−0.16, 0.01)

−0.12 (−0.27, 0.03)

−0.05 (−0.15, 0.06)

2nd Trimester

*−0.06 (−0.11, −0.01)

−0.09 (−0.15, −0.02)

−0.03 (−0.10, 0.05)

3rd Trimester

**−0.18 (−0.29, −0.06)

‡−0.08 (−0.24, 0.08)

**−0.29 (−0.45, −0.12)

Entire Pregnancy

**−0.04 (−0.07, −0.01)

−0.05 (−0.09, −0.01)

−0.04 (−0.08, 0.01)

Adjustedb

1st Trimester

−0.04 (−0.13, 0.04)

−0.11 (−0.25, 0.04)

−0.01 (−0.11, 0.09)

2nd Trimester

†−0.04 (−0.09, 0.01)

−0.07 (−0.14, −0.01)

−0.002 (−0.08, 0.07)

3rd Trimester

**−0.15 (−0.26, −0.04)

§−0.04 (−0.198, 0.11)

**−0.27 (−0.43, −0.11)

Entire Pregnancy

*−0.03 (−0.06, −0.001)

−0.04 (−0.08, 0.001)

−0.02 (−0.07, 0.02)

  1. aUnadjusted models were adjusted for child sex and age.
  2. bAll models were adjusted for child sex, maternal education, mean perceived stress during pregnancy, and mean depression during pregnancy.
  3. Interaction p-values: ‡p < 0.10, §p < 0.05.
  4. *p < 0.05; **p < 0.01.
Back to article page