Table 3 Maintenance immunosuppressant treatment and annual relapse rate in children with MNOS.

From: Less common phenotypes of myelin oligodendrocyte glycoprotein antibody-related diseases in children deserve more attention

No

Immunos

Uppressant

Duration of immunosuppressant use

Relapse rate per Year before immunosuppressant use

Annual relapse

Rate after immunosuppressant use

Maintenance Time (month)

Annual Relapse rate

  

Number of episodes

Time since the first onset (month)

    

1

MFM

2

5

2.4

0

14

0.2

2

RTX

2

3

4

0

 

0.25

3

RTX

2

4

3

0.3

14

0.5

4

MFM

3

12

2

0.5

 

0.75

5

RTX and MFM mycophenolate mofetil

3

10

2.4

0

 

0.5

6

AZA

2

24

0.5

0

19

0.2

7

MFM

2

3

4

0

35

0.25

8

/

/

/

/

/

/

0.33

9

/

/

/

/

/

/

/

10

RTX intravenous immunoglobulin

2

40

0.3

0.5

12

0.57

11

MFM

2

5

2.4

0

12

0.44

12

/

/

/

/

/

/

/

13

RTX

2

6

2

0

5

1

  1. Note: Case 8 relapsed without immunosuppressant; cases 9 and 12 did not show relapse.
  2. MFM mycophenolate mofetil, RTX rituximab, AZA azathioprine.