Table 1 NfL concentrations at days 14 and 28 and mean daily levels in the first month of life.
From: Neurofilament light chain associates with IVH and ROP in extremely preterm infants
Medians (95% CI), [range] pg/mL, n. | |||
|---|---|---|---|
Infant group | NfL day 14 | NfL day 28 | Mean NfL/day 1st month a |
All (n = 178) | 45.1 (38.6–51.2) [11.3–663.0], n = 119 | 24.1 (20.1–29.9) [6.5–1057.9], n = 149 | 55.0 (44.1–60.9) [11.9–435.2], n = 163 |
22–25 weeks GA (n = 57) | 72.7 (52.5–86.4) [19.6–663.0], n = 38 | 41.5 (32.3–54.6) [12.7–501.0], n = 48 | 77.8 (66.6–94.2) [22.3–285.9], n = 54 |
25–26 weeks GA (n = 81) | 37.4 (31.0–48.7) [11.3–365.0], n = 57 | 18.5 (15.9–23.2) [7.5–402.0], n = 69 | 43.6 (40.2–55.6) [12.9–144.9], n = 73 |
27 weeks GA (n = 40) | 24.4 (19.8–42.8) [14.6–282.0], n = 24 | 12.7 (10.5–19.9) [6.5–1057.9], n = 32 | 37.6 (28.4–43.7) [11.9–435.2], n = 36 |
Standard nutrition (n = 94) | 48.1 (40.7–55.1) [11.3–663.0], n = 65 | 25.7 (21.5–35.2) [6.5–1057.9], n = 79 | 64.1 (55.8–73.9) [12.9–435.2], n = 86 |
AA + DHA supplemented (n = 84) | 41.3 (32.0–50.2) [17.1–365.0], n = 54 | 21.4 (16.0–29.2) [6.9–501], n = 70 | 44.2 (42.6–55.0) [11.9–261.7], n = 77 |
IVH4 (n = 12) | 115.0 (81.2–246.0) [40.7–663.0], n = 8 | 46.8 (24.1–70.7) [13.4–73.3], n = 12 | 105.5 (69.3–117.5) [60.2–285.9], n = 11 |
IVH3 (n = 9) | 51.0 (35.4–71.6) [31.2–200.0], n = 8 | 36.2 (20.3–98.7) [14.6–113.0], n = 8 | 74.4 (58.0–91.8) [40.3–140.6], n = 9 |
IVH2 (n = 25) | 54.6 (50.3–181.0) [17.1–365.0], n = 21 | 38.0 (26.9–56.7) [6.9–218.0], n = 23 | 94.2 (66.6–124.4) [22.3–261.7], n = 23 |
IVH1 (n = 24) | 28.8 (24.5–43.4) [17.9–126.0], n = 16 | 19.9 (12.2–35.2) [7.4–501.0], n = 20 | 43.3 (39.1–86.0) [20.5–241.3], n = 21 |
No IVH (n = 108) | 39.7 (30.8–46.1) [11.3–144.0], n = 66 | 19.0 (15.9–23.7) [6.5–1057.9], n = 86 | 43.7 (39.0–54.2) [11.9–435.2], n = 99 |
Severe ROP (stage 3 and type 1) (n = 50) | 55.1 (48.1–73.2) [19.1–663.0], n = 35 | 36.1 (26.9–51.9) [9.9–501.0], n = 43 | 72.0 (59.9–93.6) [22.3–285.9], n = 47 |
Mild/moderate ROP (stage 1 and 2) (n = 55) | 34.0 (28.5–50.2) [16.1–183.0], n = 38 | 20.0 (17.3–30.4) [7.5–1057.9], n = 45 | 55.0 (44.1–66.5) [16.5–435.2], n = 51 |
No ROP (n = 72) | 42.8 (26.3–50.3) [11.3–365.0], n = 45 | 19.3 (14.2–25.7) [6.5–108.0], n = 60 | 41.8 (36.8–49.1) [11.9–261.9], n = 64 |
