Fig. 4: HM EVs regulate expression and secretion of cytokines and signaling proteins in human intestinal epithelial cells. | Pediatric Research

Fig. 4: HM EVs regulate expression and secretion of cytokines and signaling proteins in human intestinal epithelial cells.

From: Human milk extracellular vesicles modulate inflammation and cell survival in intestinal and immune cells

Fig. 4

Cells were treated with 20 µg/mL term or preterm HM EVs, followed by inflammatory activation with heat-killed bacteria (HKB, 109 CFU). a–g Gene expression relative to no treatment control of media only (y = 1). h, i Secretion of IL-6 and IL-8 following treatment. n = 6–16, in replicate experiments. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.04, ns=non-significant, one-way ANOVA with multiple comparisons.

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