Fig. 4: Effect of maternal Vitamin C on expression of genes regulating hypoxia signaling in the normally grown and growth restricted fetal lung. | Pediatric Research

Fig. 4: Effect of maternal Vitamin C on expression of genes regulating hypoxia signaling in the normally grown and growth restricted fetal lung.

From: Antenatal Vitamin C differentially affects lung development in normally grown and growth restricted sheep

Fig. 4

Hypoxia inducible factor (HIF)-2α a and -3α b subunits, prolyl hydroxylase domain (EGLN)-3 c and hypoxia-responsive genes vascular endothelial growth factor (VEGF, d); adrenomedullin (ADM, e) and facilitated glucose transporter 1 (SLC2A1, f). Gene data presented as Log2 fold change (compared to respective saline group) mean normalized expression (MNE) ± SD in the Normoxic Vitamin C (NVC; white circles, n = 9) and Hypoxic Vitamin C (HVC; black squares; n = 9) fetal lung. All data were evaluated for outliers ± 2 SD from the mean for each treatment group. Positive or negative mean values indicate induction or repression of gene expression, respectively. *P < 0.05; compared to respective control group, i.e. N vs. NVC or H vs. HVC. #P < 0.05; significant difference between Vitamin C effectiveness in the normally grown vs growth-restricted fetal lung (i.e NVC vs. HVC).

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