Table 3 Summary of gene expression outcome of studies using this fetal sheep model to investigate the effect of maternal chronic hypoxia and antenatal Vitamin C exposure on molecular regulation of fetal lung maturation.

From: Antenatal Vitamin C differentially affects lung development in normally grown and growth restricted sheep

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  1. This table includes summary of data included in 2 previously published studies; (1) Normoxic (N) vs Hypoxic (H) fetal lambs44 and (2) Normoxic Saline (NS) vs Normoxic Vitamin C (NVC) fetal lambs45. The findings of the current study build on this to include (1) the effect on molecular markers in the lung of H vs Hypoxic Vitamin C (HVC) lambs and (2) the magnitude of responsiveness to Vitamin C in the lung of normoxic (NVC) and hypoxic (HVC) fetuses. ↑↓=*P < 0.05; compared to respective control group in column 1 (N v H), column 2 (N v NVC) or column 3 (H v HVC) or Vitamin C effectiveness in the normally grown vs growth restricted fetal lung (column 4 = NVC vs. HVC fold change relative to respective control). ↔ no significant difference between groups. For full description of gene markers and their roles see Table 1.
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