Table 2 Multivariable model for predicting CDH survival.

From: Congenital diaphragmatic hernia outcomes: navigating center-to-center variability in level 4 NICUs in the Children’s Hospitals Neonatal Consortium

Patient Level Characteristics

OR 95% CI

p

N (%)

  

Median GA (weeks, 25–75th %ile)

1.09 (1.02, 1.16)

0.008

Female Sex (N, %)

0.67 (0.51, 0.89)

0.006

SGA (n, %)

0.65 (0.43, 0.98)

0.039

5 min Apgar < 3 (n, %)

0.47 (0.27, 0.83)

0.009

Any BSI (n, %)

0.36 (0.25, 0.5)

<0.001

Birth year

  

  2010–2013

referent

 

  2014–2016

0.93 (0.63, 1.38)

0.716

  2017–2019

1.73 (1.15, 2.62)

0.009

  2020–2023

1.52 (1, 2.32)

0.051

Antenatal diagnosis (n, %)

0.63 (0.43, 0.94)

0.022

Pre-repair thoracostomy tube (n, %)

0.46 (0.29, 0.74)

0.001

Congenital Heart Disease

  

  None

referent

 

  ASD/VSD

0.83 (0.58, 1.2)

0.322

  Other CHD

0.29 (0.16,0.5)

<0.001

Lowest pH in first 12 h after admission

  

  <7.0

referent

 

  7.0–7.19

1.84 (1.19, 2.83)

0.006

  7.2–7.29

3.75 (2.33, 6.03)

<0.001

  7.3–7.45

4.96 (2.97, 8.28)

<0.001

  >7.45+

5.8 (2.1, 16.03)

<0.001

Liver Position in Thorax (n, %)

0.5 (0.36, 0.7)

<0.001

Primary repair (n, %)

2.36 (1.63, 3.41)

<0.001

Genetic Diagnoses

0.46 (0.23, 0.9)

0.024

Kidney Failure

0.06 (0.04, 0.11)

<0.001

  1. SGA criteria based on Olsen et al.11; Each center was included in the models as a fixed effect.
  2. BSI blood stream infection, culture positive only, ASD atrial septal defect, VSD ventricular septal defect, AVSD atrioventricular septal defect.