Table 1 Variance in dosage regimens in high-dose RCTs.

From: Caffeine and preterm infants: multiorgan effects and therapeutic creep: scope to optimise dose and timing

 

Romangnoli, et al.60

Scanlon et al.61

Gray et al.62

Steer et al.63

Mohammed et al.65

McPhearson et al.64

High dose (mg/kg/day)

LD:10

LD:50

LD:80

LD:60

LD:40

LD:80

MD:5

MD:12

MD:20

MD:30

MD:20

MD:10

Low dose (mg/kg/day)

LD:10

LD:25

LD:20

LD:6

LD:20

LD:30

MD:2.5

MD:6

MD:5

MD:3

MD:10

MD:10

  1. LD loading dose, MD maintenance dose.
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