Table 1 cCMV disease classification.

From: Beyond hearing loss: exploring neurological and neurodevelopmental sequelae in asymptomatic congenital cytomegalovirus infection

Definitions of cCMV Disease Categoriesa

Symptomatic cCMV Infection with CMV Disease/Clinically Apparent cCMV (CACMV)

Mildly Symptomatic cCMV Disease

• Defined as cCMV infection with one or two isolated disease manifestations.

• Clinical or laboratory findings are mild and transient (eg, mild hepatomegaly; a single measurement of low platelet count or elevated transaminases).

• No evidence of neuroimaging abnormalities or SNHL.

Moderately-to-Severely Symptomatic cCMV Disease

• Multiple disease manifestations attributable to cCMV: thrombocytopenia, petechiae, hepatomegaly, splenomegaly, intrauterine growth restriction, or hepatitis (raised transaminases or bilirubin).

• CNS involvement including microcephaly, radiographic abnormalities (ventriculomegaly, intracerebral calcifications, periventricular echogenicity, cortical or cerebellar malformations), abnormal cerebrospinal fluid findings including detection of CMV DNA in cerebrospinal fluid, chorioretinitis, SNHL.

Asymptomatic cCMV Infection/Clinically Inapparent cCMV (CICMV)

Asymptomatic cCMV Disease with Isolated SNHL

• No apparent abnormalities to suggest cCMV disease, but sensorineural hearing loss (≥21 decibels) detected by audiological evaluation.

Asymptomatic cCMV

• No apparent abnormalities to suggest cCMV disease, and documentation of normal hearing by audiologic evaluation.

  1. aAfter Rawlinson et al., Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.33
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