Table 5 Recommendations for infant MRI scan in setting of cCMV infection.

From: Beyond hearing loss: exploring neurological and neurodevelopmental sequelae in asymptomatic congenital cytomegalovirus infection

Recommendations for MRI Scan in Infants with cCMV

Recommended

• Maternal history of primary CMV infection (seroconversion/virologically confirmed maternal CMV disease) or documentation of maternal re-infection in pregnancy.

• cCMV in the context of prenatal ultrasonography abnormalities.

• History of maternal valacyclovir therapy for prevention of cCMV transmission.

• Small for gestational age or microcephaly.

• Asymptomatic cCMV disease (as defined by Table 1) with isolated SNHL.

• Ophthalmologic abnormalities.

• Any screening cranial ultrasonographic abnormality.

• Moderate-to-severe symptomatic cCMV (as defined in Table 1).

Consider

• Progressive emergence of SNHL on serial audiological evaluation in infancy.

• Abnormal head growth.

• Abnormal neurodevelopmental milestones.

• Any case with mildly symptomatic cCMV disease (as defined in Table 1).

• Infants with asymptomatic cCMV infection (as defined in Table 1) on a case-by-case basis.

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