Fig. 2: U. parvum elicits stronger alveolar epithelial inflammation than U. urealyticum. | Pediatric Research

Fig. 2: U. parvum elicits stronger alveolar epithelial inflammation than U. urealyticum.

From: Ureaplasma parvum and Ureaplasma urealyticum induce distinct types of inflammation in neonates and human epithelial cell models

Fig. 2

Alveolar epithelial cells were inoculated with three different strains of U. urealyticum (UU) or U. parvum (UP) at MOI 1 and MOI 10. Three strains of each species were tested: UP#1 = U. parvum clinical isolate 2990, UP#2 = U. parvum ATCC 700970, UP#3 = U. parvum ATCC 27815; UU#1 = U. urealyticum ATCC 27618, UU#2 = U. urealyticum ATCC 27817, UU#3 = U. urealyticum clinical isolate 2983. After 24 h, the levels of pro-inflammatory cytokines and chemokines in these supernatants were determined by a, d ELISA (IL-6) and b, c, e–l LEGEND-plex, respectively. Bars represent the mean ± SD of triplicate cultures. Representative results of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 (One-way ANOVA followed by Dunnett’s multiple comparison test).

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