Table 2 Brain volumes by enteral nutrition type.

From: Donor human milk and structural brain development in very preterm infants

  

Comparison to MOM

 

Brain volume (cm3)a Mean (SD)

DHM

PTF

Brain Region

MOM (n = 67)

DHM (n = 44)

PTF (n = 41)

β (95% CI)b

p

Β (95% CI)b

p

Total Brain Volume

324.5 (46.7)

303.7 (43.7)

308.6 (55.2)

–5.9 (–19.9, 8.1)

0.40

–17.2 (–31.1, –3.3)

0.016*

Cortical Gray Matter

128.1 (23.6)

118.6 (23.4)

121.5 (27.9)

–1.7 (–8, 4.6)

0.56

–7.0 (–13.2, –0.8)

0.028

White Matter

144.6 (17.9)

135.7 (17.5)

137 (22.7)

–3.8 (–10.6, 2.9)

0.26

–7.6 (–14.3, –0.9)

0.026

Deep Gray Matter

24.2 (2.7)

23 (3.2)

23.1 (3.7)

–0.5 (–1.5, 0.6)

0.39

–1.2 (–2.2, –0.2)

0.024*

Amygdala-Hippocampus

2.3 (0.4)

2.2 (0.4)

2.2 (0.5)

–0.0 (–0.2, 0.1)

0.79

–0.1 (–0.2, 0.1)

0.21

Cerebellum

20.9 (4.8)

19.1 (5)

19.7 (5.2)

–0.3 (–1.8, 1.1)

0.65

–1.3 (–2.8, 0.1)

0.06

Brainstem

5.5 (0.8)

5.1 (0.7)

5.1 (0.6)

–0.2 (–0.4, 0.1)

0.16

–0.4 (–0.6, –0.2)

0.002*

  1. *Significant p value < 0.025.
  2. aUnadjusted mean.
  3. bGeneralized linear model adjusting for gestational age at birth and postmenstrual age at term-equivalent MRI with MOM as reference group.
  4. MOM Mother’s own milk, DHM donor human milk, PTF preterm formula.
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