Table 5 Brain volumes and diffusion tensor imaging between donor human milk and formula-fed infants.

From: Donor human milk and structural brain development in very preterm infants

Brain Volumes

Diffusion Tensor Imaging

Mean Diffusivity (x10−3 mm2/second)

Fractional Anisotropy

Brain region

β (95% CI)a

p

Brain Region

β (95% CI)a

p

β (95% CI)a

p

Total Brain Volume

10.2 (–7.0, 27.3)

0.24

Corpus Callosum

 Genu

 Splenium

–0.17 (–0.25, –0.08)

–0.15 (–0.26, –0.04)

<0.001*

   0.010*

(–0.03, 0.06)

0.03 (–0.02, 0.07)

0.50

0.26

Cortical Gray Matter

4.9 (–2.7, 12.4)

0.20

White Matter

3.5 (–4.8, 11.8)

0.40

Posterior Limb of Internal Capsule

 Right

 Left

–0.08 (–0.12, –0.05)

–0.09 (–0.13, –0.05)

<0.001*

<0.001*

(0.00, 0.05)

0.02 (-0.01, 0.04)

0.07

0.16

Deep Gray Matter

0.7 (–0.7, 2.0)

0.34

Amygdala-Hippocampus

0.1 (–0.1, 0.2)

0.44

Cerebellum

1.0 (–0.8, 2.7)

0.29

Brainstem - Pons

 Right

 Left

–0.06 (–0.1, –0.03)

–0.06 (–0.09, –0.03)

<0.001*

<0.001*

–0.04 (–0.08, –0.01)

–0.04 (–0.07, –0.01)

0.018*

0.025

Brainstem

0.2 (–0.1, 0.4)

0.12

  1. *Significant p value <0.025.
  2. aGeneralized linear model adjusting for gestational age at birth and postmenstrual age at term-equivalent MRI with PTF as reference group.