Table 2 Top 20 named metabolites with difference in levels between eCPAP and dCPAP infants.

From: Metabolic response to extended continuous positive airway pressure in premature infants

Biochemical Name	Super Pathway	Sub Pathway	eCPAP/dCPAP			Detected
			fold	p	q	%
Higher IN eCPAP
histidylphenylalanine	Peptide	Dipeptide	13.75	<0.00001	<0.00001	63
2-aminoheptanoate	Lipid	FA, Amino	2.82	<0.00001	<0.00001	100
Glucuronate	Carbohydrate	Aminosugar Metabolism	1.52	<0.00001	0.00001	100
Pregnenediol disulfate	Lipid	Pregnenolone Steroids	1.79	0.0008	0.0345	100
Nicotinamide riboside	Cofactors/Vitamins	Nicotinamide Metabolism	1.27	0.0008	0.0345	100
N1-methyladenosine	Nucleotide	Purine Metabolism, adenine	1.14	0.0008	0.0345	100
N-acetyltheanine	Xenobiotics	Food Component/Plant	1.75	0.001	0.0365	96
Creatinine	Amino Acid	Creatine Metabolism	1.15	0.0021	0.0561	100
Glycochenodeoxycholate 3-sulfate	Lipid	Primary Bile Acid Metabolism	2.09	0.0027	0.0693	100
Glycolithocholate sulfate	Lipid	Secondary Bile Acid Metabolism	1.66	0.0032	0.0814	70
Lower IN eCPAP
Bilirubin degrade product C16H18N2O5(3)	Partially Characterized	Partially Characterized	0.42	<0.00001	<0.00001	73
Dihydroorotate	Nucleotide	Pyrimidine Metabolism, Orotate	0.52	<0.00001	<0.00001	100
Propionylcarnitine(C3)	Lipid	FA Metabolism (Acylcarnitine)	0.58	<0.00001	0.0007	100
Spermidine	Amino Acid	Polyamine Metabolism	0.65	<0.00001	0.0081	100
Bilirubin degrade product C16H18N2O5(1)	Partially Characterized	Partially Characterized	0.62	0.0001	0.0093	76
Bilirubin degrade product C17H18N2O4(1)	Partially Characterized	Partially Characterized	0.46	0.0002	0.0114	100
Myristoylcarnitine(C14)	Lipid	FA Metabolism (Acylcarnitine)	0.67	0.0003	0.015	100
Creatine	Amino Acid	Creatine Metabolism	0.81	0.0006	0.0325	100
Deoxycarnitine	Lipid	Carnitine Metabolism	0.79	0.0007	0.0345	100
Dihomo-linoleoylcarnitine	Lipid	FA Metabolism (Acylcarnitine)	0.73	0.003	0.0365	100

Metabolites in each category ordered by p and q value (ANCOVA).
% Detected, percent of all samples with level above lower limit of detection; p values < 0.05 in bold.
FA fatty acid.

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Table 2 Top 20 named metabolites with difference in levels between eCPAP and dCPAP infants.

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