Table 3 Differential metabolites enriched by sub-pathway category.

From: Metabolic response to extended continuous positive airway pressure in premature infants

Sub-Pathway

Metabolites with p < 0.05/total

Fold enrichment

 

eCPAP Levels

 

Observed

Expected

Observed/

 

Higher

Lower

Expected

p

Bilirubin synthesis/degradation

10/10

1.4/10

7.1

0.0001

0

10

FA metabolism (all acyl carnitines)

22/46

6.3/46

3.5

0.0005

0

22

FA metabolism (acyl carnitine, polyunsaturated)

7/8

1.1/8

6.4

0.011

0

7

FA metabolism (acyl carnitine, hydroxy)

5/8

1.1/8

4.5

0.12

0

5

FA metabolism (acyl carnitine, monounsaturated)

5/11

1.5/11

3.3

0.15

0

5

  1. Enriched sub-pathways from a total of 86 sub-pathways with ≥3 metabolites.
  2. Expected value is fraction of total metabolites differing at p < 0.05 (0.139) x number of metabolites in sub-pathway.
  3. Data were rounded to the nearest integer for calculation of p value (Fisher exact test).
  4. p values < 0.05 in bold.
Back to article page