Fig. 1: Study design and overview of FM sampling and proteomic profiling.
From: Proteomic comparison of intact and fetoscopy-induced fetal membrane defect sites
a Overview of a FM after delivery, highlighting the fetoscopically induced defect site. The blue lines indicate the regions of interest, which were sectioned for analysis. One side of each section was used for proteomics, and the other for histology. b Principal Component Analysis (PCA) plot of normalized proteomics data, colored by tissue type (chorion, amnion, and full membrane) and shaped according to the position within the FM. c Gestational age at fetoscopic intervention (x) and delivery (o) for each donor. d Histogram of the distribution of p-values for differentially expressed proteins, grouped by tissue type (chorion, amnion, full membrane), location (defect site, control 1, control 2, control 3), and donor.
