Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma

Fig. 3

Novel repression motifs are essential for the regulation of HCC cell metastasis by Tbx3. a–c Transwell assay of cell invasion in stable HepG2 cells that overexpress Tbx3 WT or Tbx3 mutant. d–f Overexpression of Tbx3 WT in HepG2 cells induced liver metastasis more frequently than the cells with expression of the Tbx3 mutant after intrasplenic injection. g Metastatic ability and tumorigenicity of HepG2 cells with wild-type Tbx3 or mutant Tbx3 in nude mice

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