Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma

Fig. 5

Tbx3 and HDAC5 cooperate in the regulation of HCC cell migration and E-cadherin expression. a–c Wound healing assay was performed to detect migration of HepG2 cells. Decreased migration of HepG2 cells appeared after treatment with the HDAC inhibitor NaB. d WB analysis of E-cadherin in Tbx3 WT or mock cells with or without NaB treatment. e WB analysis of E-cadherin in Tbx3 siRNA- or/and HDAC5 siRNA-treated cells. f–i RT-qPCR analysis of the E-cadherin mRNA level in the indicated transfected cells

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