Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells

Fig. 2

Comparison of the global gene expression profiles of patients showing a strong response to insulin and patients showing decreased phosphorylation of at least one substrate in the PI3K-Akt-mTOR pathway after exposure to insulin. The comparison included 30 unselected patients, and 45 discriminative genes were selected based on FSS analysis and overrepresentation of GO terms. Hierarchical clustering was performed by Pearson’s correlation and the weighted pair group method with arithmetic mean to measure distance. The figure shows the heat map and the corresponding dendrograms based on gene and patient clustering. The red bars at the top of the figure indicate patients with a strong effect of insulin, and the blue bars indicate decreased phosphorylation for at least one substrate. The discriminative genes are listed in the right column

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