Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis

Fig. 7

Before and after oxLDL treatment, the IFN-γ-mediated promotion of cell apoptosis and inflammatory factor production were reversed by IDO1 inhibition. a Western blot analysis of caspase-3 expression in THP-M. b The mRNA levels of IL-10, MCP-1, IL-1β and IL-8 were measured by real-time PCR. The designation of different treatments, such as IFN-γ+oxLDL, oxLDL+IFN-γ, IFN-γ+Incyte+oxLDL, oxLDL+IFN-γ+Incyte, IFN-γ+1-MT+oxLDL and oxLDL+IFN-γ+1-MT, was described in the Materials and Methods. Data were based on at least three independent experiments. *p < 0.05, **p < 0.01

Back to article page