Fig. 2
From: Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence
SerRS functions as a tumor suppressor and correlates with better prognosis of cancer patients. a Kaplan–Meier plots and hazard ratio analysis of human tRNA synthetases reveal a tight correlation with relapse-free survival (RFS) of breast cancer patients. Patient samples were divided into two halves as “low-expression” (black)” and “high-expression” (red) sets for each tRNA synthetase in the analysis (n = 1764). b, c HeLa cells stably transfected with the SerRS expression vector or the empty vector were injected subcutaneously into NOD/SCID mice (n = 5 in each group), and the growth curves of the tumor xenograft were monitored b (***P <0.001, two-tailed Student’s t-test). The dissected tumor xenografts are shown in c. d, e Immunohistochemistry analysis of β-Gal, P21 and P16 to show cellular senescence in the indicated xenografts d, and the protein levels were quantified based on the H-score e (**p < 0.01, ***p < 0.001)
