Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: FGF/FGFR signaling in health and disease

Fig. 3

The regulation of FGF15/19 on energy metabolism. FGF15/19 regulates energy metabolism both peripherally and centrally. In the liver, FGF15/19 inhibits BA production and promotes gallbladder filling. As for lipid and glucose metabolism, FGF15/19 improves glycogen synthesis, but suppresses lipogenesis and gluconeogenesis. In the adipose tissue, FGF15/19 promotes energy expenditure and fatty acid oxidation. In the brain, FGF15/19 promotes the expression of CRF in the hypothalamus and stimulates sympathetic nerve activity, and then increases energy expenditure in the adipose tissue. Furthermore, FGF15/19 promotes peripheral insulin sensitivity and glucose metabolism by repressing HPA axis and AGRP/NPY neuron activity. AGRP agouti-related protein, BA bile acid, HPA hypothalamic-pituitary-adrenal, NPY neuropeptide Y

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