Scheme 1 | Signal Transduction and Targeted Therapy

Scheme 1

From: Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma

Scheme 1

Schematic illustration of GSH-scavenging nanoparticles for synergistic suppression of chemotherapy-resistant osteosarcoma. Single-cell transcriptomics indicate VEGFR2-JMJD3-abundant cells in the stem-like/progenitor populations in osteosarcoma. NPJ4+Apa could effectively load and release the Apa (VEGFR2 inhibitor) and J4 (JMJD3 inhibitor), increase endoplasmic reticulum stress-induced apoptosis, and exhibit significant potency against osteosarcoma stem-like/progenitor cell-derived tumors

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