Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer

Fig. 1

Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer. a Kaplan–Meier curve of overall survival among GBC patients stratified based on BMP2K expression. b GO analysis of BMP2K and its interaction proteins in Metascape. c Co-IP between endogenous BMP2K and AP2M1 or ALOX15. d CCK8 analysis of siBMP2Kand AP2M1 or AP2M1-T156A-expressing NOZ cells. e Corresponding protein changes in ALOX15-shRNA, overexpressing, or inhibitor-treated cells by western blotting analysis. f Human XL Oncology Array Kit from RandD Systems was used to identify the novel mediators in GBC cells. g As overexpression AP2M1 treated with EGF or Dynasore (50 mM) for 2 h, membrane surface EGFR was measured by western blotting analysis. h A proposed scheme of EGFR internalization regulated by ALOX15–BMP2K–AP2M1 axis

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