Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance

Fig. 5

Vimentin and MMP3 mediate the effect of miR-515-3p on cancer cell mobility. a The I6 and LM3 cells co-overexpressing miR-515-3p and vimentin, or miR-515-3p and MMP3, were assayed for EMT marker expression by western blotting. b Comparison of the invasive potential of the cells co-overexpressing miR-515-3p and vimentin, or miR-515-3p and MMP3, as well as the control cells, by chamber invasion assay. c, d Expression of vimentin or MMP3 was further inhibited in the miR-515-3p-knockdown ESCC cells, and EMT marker expression and invasive ability of the cells were compared with control cells by western blotting (c) and chamber invasion assay (d), respectively

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