Fig. 5
From: COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm
Pharmacological inhibition of NF-κB signaling and SREBP-2 prevent lung tissue damage and rescue survival rate in infectious disease mouse model. a Survival rate of sepsis mouse model after the cecal ligation and puncture (CLP). The inhibition of NF-κB signaling (SN50) and SREBP-2 (Fatostatin A and shSREBP-2) rescued the survival rate to 30–40%. b Histology of mouse lung tissue with or without the pharmacological inhibition (Scale bar: 100 μm). c Levels of tissue damage markers with or without the pharmacological inhibition. Liver damage marker: aminotransferase (AST) and alkaline phosphatase (ALP). Kidney damage marker: blood urea nitrogen (BUN). Inflammation marker: C-reactive protein (CRP) and lactate dehydrogenase (LDH). d Levels of cytokines (IL-1β, IL-6, and TNF-α), chemokine (monocyte chemoattractant protein-1 (MCP-1)), and SREBP-2 C-term. (*p < 0.05)
