Table 4 Clinical features and laboratory results before and after convalescent plasma transfusion
After CP transfusion | ||||||
|---|---|---|---|---|---|---|
Before CP transfusion | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | |
Clinical characteristics | ||||||
Body temperature, °C | 36.5 (36.3–36.6) | 36.6 (36.2–36.9) | 36.6 (36.3–36.9) | 36.6 (36.3–36.8) | 36.5 (36.3–36.8) | 36.4 (36.3–37.1) |
Respiratory rate, per min | 19.5 (19.0–25.5) | 21.0 (20.0–23.5) | 20.5 (20.0–21.0) | 21.5 (19.0–22.0) | 20.0 (19.3–21.8) | 20.0 (19.0–25.0) |
Heart rate | 77.5 (64.0–92.5) | 81.0 (72.0–87.8) | 78.0 (62.5–88.0) | 84.5 (73.3–91.5) | 87.0 (79.8–89.8) | 100.0 (81.5–121.5) |
Systolic pressure | 118.0 (105.0–129.0) | 112.5 (106.8–119.5) | 116.0 (114.5–128.0) | 116.5 (109.0–123.3) | 108.0 (106.0–116.0) | 118.0 (109.5–125.8) |
PaO2/FiO2 (normal range, 400–500 mmHg) | 259.0 (163.0–283.0) | 312.0 (246.0–409.0) | 318.0 (279.5–416.0) | 225.0 (194.5–444.5) | 290.0 (196.0–493.5) | 326.0 (215.3–556.0) |
Laboratory results | ||||||
WBC count × 109/L (normal range, 3.5–9.5) | 7.5 (5.5–8.4) | 8.3 (7.0–9.2) | 7.4 (5.5–7.9) | 6.6 (5.5–9.9) | 6.7 (5.8–10.9) | 7.9 (5.6–13.2) |
NE count × 109/L (normal range, 1.8–6.3) | 6.1 (4.4–7.3) | 6.9 (4.5–8.4) | 5.7 (4.7–6.9) | 5.0 (4.2–8.4) | 4.5 (3.5–9.0) | 6.0 (3.5–11.8) |
LY count × 109/L (normal range, 1.1–3.2) | 0.4 (0.2–1.5) | 0.7 (0.3–1.2) | 0.8 (0.2–1.2) | 0.8 (0.4–1.3) | 1.1 (0.5–1.5) | 1.1 (0.7–1.4) |
CRP, mg/L (normal range, <8) | 10.9 (7.7–94.0) | 11.7 (8.1–51.4) | 41.7 (9.5–66.8) | 24.9 (6.3–107.4) | 24.1 (6.1–95.2) | 41.9 (5.0–58.1) |
PCT, ng/mL (normal range, <0.1) | 0.15 (0.06–0.38) | 0.09 (0.05–0.18) | 0.05 (0.05–0.13) | 0.04 (0.03–0.12) | 0.04 (0.01–0.09) | 0.01 (0.01–0.11) |
IL-2, pg/mL (normal range, 0–5.71) | 1.1 (0.6–1.6) | 0.9 (0.6–0.9) | 0.8 (0.6–3.6) | 1.3 (1.0–2.1) | 0.5 (0.4–1.3) | 1.0 (0.5–2.7) |
IL-4, pg/mL (normal range, 0–2.80) | 1.6 (0.7–2.1) | 0.5 (0.3–2.4) | 1.4 (0.7–3.3) | 1.5 (0.4–2.2) | 0.4 (0.2–1.1) | 0.7 (0.6–5.1) |
IL-6, pg/mL (normal range, 0–5.30) | 7.8 (1.8–26.8) | 10.5 (1.1–12.8) | 12.7 (5.1–32.8) | 11.6 (4.3–68.0) | 23.6 (4.3–58.3) | 6.6 (5.5–35.6) |
IL-10, pg/mL (normal range, 0–4.91) | 3.1 (2.6–3.7) | 3.3 (2.3–10.9) | 3.6 (2.5–6.9) | 3.6 (3.5–3.7) | 3.5 (2.7–3.9) | 3.8 (3.3–4.1) |
IL-17A, pg/mL (normal range, 0–20.60) | 8.2 (0.7–17.0) | 1.5 (0.7–8.3) | 1.5 (0.0–24.5) | 14.0 (3.4–26.7) | 8.2 (0.0–12.7) | 12.3 (1.5–52.0) |
TNF-α, pg/mL (normal range, 0–2.31) | 3.3 (0.6–3.7) | 1.5 (1.3–5.5) | 3.2 (1.2–5.8) | 2.4 (1.2–4.6) | 1.2 (0.9–2.1) | 2.3 (1.4–5.8) |
IFN-γ, pg/mL (normal range, 0–7.42) | 1.4 (1.3–2.8) | 2.7 (1.0–4.7) | 1.5 (1.1–3.7) | 2.3 (1.3–3.6) | 1.3 (1.0–2.4) | 2.2 (0.6–4.4) |
IL-6/IL-10 | 1.4 (0.6–4.0) | 0.7 (0.3–1.4) | 4.2 (2.0–13.3) | 2.3 (1.2–10.1) | NA | 1.7 (1.5–4.2) |
IL-6/IL-4 | 4.5 (2.0–4.7) | 12.4 (5.6–19.7) | 9.6 (3.7–46.9) | 19.3 (4.3–50.3) | NA | 9.5 (6.9–20.9) |
ALT, μ/L (normol range, 5–40) | 21.1 (14.3–47.0) | 22.0 (17.0–49.5) | 22.0 (14.5–49.1) | 23.0 (18.0–51.7) | 20.4 (15.8–40.2) | 27.8 (14.0–65.0) |
AST, μ/L (normol range, 13–35) | 20.2 (16.3–30.8) | 19.0 (16.4–25.0) | 18.0 (15.5–30.3) | 18.0 (16.0–32.3) | 17.0 (15.3–24.0) | 18.4 (14.0–33.6) |
TBIL, μmol/L (normal range, 0–26) | 17.5 (7.1–24.7) | 10.4 (6.6–15.4) | 10.4 (5.8–15.8) | 12.0 (9.2–14.2) | 10.4 (6.3–16.6) | 10.8 (9.6–24.6) |
PT, second (normal range, 11–14) | 11.3 (10.6–12.4) | 11.3 (10.1–13.3) | 10.6 (9.5–12.9) | 10.4 (9.6–13.9) | 10.5 (9.6–13.4) | 10.9 (10.1–12.9) |
D-dimer, mg/mL (normal range, 0–0.05) | 1.2 (0.5–4.0) | 1.0 (0.4–5.7) | 0.9 (0.6–5.3) | 0.8 (0.6–5.4) | 1.1 (0.6–4.2) | 1.2 (0.8–3.3) |
