Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: TREM2 marks tumor-associated macrophages

Fig. 1

TREM2 is a key target to modulate tumor-associated macrophages (TAMs). TREM2 marks tumor-associated monocytes/macrophages with potent immunosuppressive activity by arginase-1 (Arg1) (left). The absence of TREM2 dramatically alters the immune microenvironment, leading to better antitumor immunity (right)

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