Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Development of synthetic lethality in cancer: molecular and cellular classification

Fig. 6

Timeline: landmark discoveries and advances of synthetic lethality in cancer. Several key events of synthetic lethality development. Several expanded concepts of SL beyond the original have been constantly proposed. In contrast, after Ashworth and Helleday demonstrated synthetic lethality of PARP inhibitors in BRCA1/2-deficient tumors, numerous studies on SL in cancer has been significantly increased and several inhibitors, especially PARPi based on SL, has been applied in clinical practice

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