Table 1 Representative synthetic lethal interactions among genes in preclinical studies
From: Development of synthetic lethality in cancer: molecular and cellular classification
Gene | Chromosome | Cellular process and mechanism | SL partners | Cancer type | Reference |
|---|---|---|---|---|---|
PARP1 (mutant) | 1q41.42 | Regulate cell proliferation and differentiation; repair DNA single- and double-strand breaks. | BRCA1/2 | Breast, ovarian, pancreatic and liver cancer; leukemia | |
RAD51 | Ovarian cancer; HCC | ||||
ATG5 | Ovarian cancer | ||||
CDK5 | Cervical and breast cancer | ||||
TP53 (mutant) | 17p13.1 | Major tumor suppressor; regulate the cell cycle, senescence, and apoptosis. | ATM | Glioma | |
ATR | CLL; osteosarcoma, colon and breast cancer | ||||
WEE1 | HNSCC | ||||
CHK1 | NSCLC, B-ALL | ||||
BCL-2 | AML | ||||
SLC711 | NSCLC; renal, esophagus, cervical and gastric cancer | ||||
mTOR | Pancreatic adenocarcinoma; lung and breast cancer | ||||
AURKA | Liver cancer | ||||
PIP4KB | Breast Cancer | ||||
KRAS (mutant) | 12p12.1 | Transcriptional activator that regulates endothelial cells endothelin-1 gene expression. | CDC6 | Colon cancer | |
GATA2 | Colon cancer; NSCLC | ||||
SLC25A22 | Colorectal cancer | ||||
PLK1 and ROCK | Lung and pancreatic cancer | ||||
CD274 | Colon and lung cancer | ||||
MYC (mutant) | 8q24.21 | Regulate cell cycle progression, transcription, and apoptosis. | 4EBP1 | Hematological cancer | |
SAE1/2 | Breast cancer | ||||
AURKB | T-ALL | ||||
PIM1 | Breast cancer | ||||
CDK9 | HCC | ||||
ARID1A (mutant) | 1p36.11 | Target SWI/SNF complexes, which regulate chromatin remodeling. SWI/SNF complexes are involved in controlling the cell cycle, DNA replication, and repairing DNA damage. | ARID1B | Ovarian cancer | |
EZH2 | Ovarian cancer | ||||
PARP1 | Breast and colon cancer | ||||
MAD2 (overexpress) | 4q27 | A component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. | PP2A | Lung and liver cancer; malignant lymphoma | |
CKS1B (overexpress) | 1q21 | Codes for a conserved regulatory subunit of cyclin-CDK complexes that function at multiple stages of cell cycle progression | PLK1 | Breast cancer | |
TDP1 (overexpress) | 14q32.11 | Encode the protein that repairs stalled topoisomerase I-DNA complexes and repair of free-radical mediated DNA double-strand breaks. | HDAC1/2 | Fibrosarcoma; rhabdomyosarcoma | |
RPD3 |
