Fig. 1: Proteomic and metabolic/lipidomic profiling of colostrum samples from COVID-19 puerperant women and healthy volunteers. | Signal Transduction and Targeted Therapy

Fig. 1: Proteomic and metabolic/lipidomic profiling of colostrum samples from COVID-19 puerperant women and healthy volunteers.

From: Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19

Fig. 1

a Overview of colostrum samples collected from COVID-19 puerperant women (n = 4) and healthy volunteers (n = 2). The workflow for processing the omics study was shown. b GO and KEGG analyses were performed using DEPs in colostrum samples. The count number ≥ 5, two-sided hypergeometric test, P < 0.05. c The fold changes of DEPs (COVID-19 vs. Healthy) in the indicated process. d The catabolism of tryptophan in breastmilk. ASMT acetylserotonin o-methyltransferase, DDC aromatic L-amino acid decarboxylase, TDO tryptophan 2,3-dioxygenase, IDO indoleamine 2,3-dioxygenase, ipdC indole pyruvate decarboxylase, ALDH aldehyde dehydrogenase, tnaA tryptophanase. The solid line represents the one-step reaction; the dashed line represents the multiple reaction. e The catabolism of phenylalanine and tyrosine in breastmilk. PAL phenylalanine ammonia-lyase, DDC aromatic L-amino acid decarboxylase, PAH phenylalanine 4-hydroxylase, TAL tyrosine ammonia-lyase. The solid line represents the one-step reaction; the dashed line represents the multiple reaction. f A regulatory network of differentially expressed proteins and aromatic amino acids with the derivatives associated with COVID-19

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