Table 2 LPA receptors: molecular characteristics
From: Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Receptor | Number of residues | Molecular weight (kDa) | Chromosomal localization of genes in humans | Number of exons | Similarity to other receptors (in %) | Role of various residues in function (interaction with LPA) |
|---|---|---|---|---|---|---|
LPAR1 or Edg2 | 364 Amino acids | ∼41 | 9q31.3 | Five exons | ||
LPAR2 or Edg4 | 348 Amino acids | ∼39 | 19p12 | Five exons | ∼50% identical at the amino acid level to LPAR1. | |
LPAR3 or Egd7 | 353 Amino acids | ∼40 | 1p22.3–p31.1 | Five exons | ∼50% identical in amino acid sequence to LPAR1 and LPAR2 (mice) | Preference for 2-acyl-LPA rather than 1-acyl-LPA |
LPAR4 or P2Y9 or GPR23 | 370 Amino acids | ∼42 | Xq21.1 | Five exons | Less than 20% amino acid sequence identity with LPAR1, LPAR2 and LPAR3 | |
LPAR5 or GPR92/93 | 372 Amino acids | ∼41 | 12p13.31 | Three exons | ∼35% homology with LPAR4 | |
LPAR6- P2Y5 | 344 Amino acids | ∼39 | 13q14 | Ten exons | Preference for 2-acyl-LPA rather than 1-acyl-LPA | |
GPR87 | 358 Amino acids | ∼41 | 3q25.1 | Three exons | Share 27% and 25% similarity with LPAR4 and LPAR5, respectively | |
P2Y10 | 364 Amino acids | ∼39 | Xq21.1 | Five exons | ||
TRPV1 | 839 Amino acids | ~100.7 | 17p13.2 | Nineteen exons | Activated only by LPA (18:1) |
