Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia

Fig. 1

CBS and H2S levels were increased in pediatric CML patients and CML-derived K562 cells. The CBS, CSE, and 3-MST mRNA levels (a) and bone marrow H2S levels (b) in CML patients (n = 17) and the controls (n = 24) were measured by RT-PCR and methylene blue assay, respectively. The CBS mRNA levels (c) and bone marrow H2S levels (d) in the controls (n = 24) and different stages of CML (n = 8 of chronic phase, n = 6 of accelerated phase, n = 3 of blastic phase). e CD34+ umbilical cord hematopoietic stem cells were extracted from the neonatal cord blood. The protein levels of CBS, CSE, and 3-MST in CD34+ cells and CML-derived K562 cells were detected by Western blot (n = 3). The results are expressed as mean ± SEM. Statistical significance was determined by Mann–Whitney test, ANOVA followed by Tukey’s multiple comparisons test or two-tailed Student’s t test

Back to article page