Table 2 Classifications and functions of DUBs
From: Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways
Classification | Abbreviation | Full name | Functions | References |
|---|---|---|---|---|
Cysteine proteases | USPs | Ubiquitin-specific proteases | (1) removal of ubiquitination to stabilize proteins and protect them from ubiquitination-proteasomal degradation; (2) processing and maturation of ubiquitin precursors; (3) cleaving poly-ubiquitin chains to recycle ubiquitin; (4) editing ubiquitin chains from one to another to adapt different activities. | |
| Â | UCHs | Ubiquitin carboxyl-terminal hydrolases | Â | Â |
| Â | OTUs | Otubain/ovarian tumor-domain containing proteins | Â | Â |
| Â | MJDs | Machado-Joseph disease domain superfamily | Â | Â |
| Â | MINDYs | Motif interacting with ubiquitin containing DUB family | Â | Â |
Zinc-dependent metalloproteases | JAMMs | JAB1/MPN/MOV34 proteases | Â | Â |
