Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Fig. 3

The mechanisms of actions of EETs on tumor growth. EETs accelerated proliferation, cell cycle, and protected carcinoma cells from apoptosis through multiple signal transduction pathways. Besides, EETs improved mitochondrial function and prevented carcinoma cells from oxidative stress damage. In addition, EETs also were found to regulate multiple important cells in TME, such as promoting endothelial cell angiogenesis, fibroblast activation, and anti-inflammation

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