Fig. 3
From: The role of m6A modification in the biological functions and diseases
m6A RNA methylation regulates central nervous system development. Neural stem/progenitor cells have the potential to self-renewal, which can differentiate to produce various types of nervous cells, including neurons, astrocytes, and oligodendrocytes. YTHDF2 and FTO promote the self-renewal and proliferation of NSCs by regulating the JAK/STAT and PI3K/AKT signaling pathways. METTL14 and METTL3 promote cortical biogenesis by accelerating the cell cycle of radial glial cells. PRRC2A and METTL14 promote the proliferation and differentiation of oligodendrocyte precursor cells and the myelination process by promoting the expression of Olig2 and NF155, respectively. YTHDF1 regulates learning and memory by promoting synaptic transmission and transcription of LTP-related target genes in neurons
